https://www.profacgen.com/protein%E2%80%93nucleic-acid-docking.htm The interactions between protein and nucleic acids play essential roles in various essential biological processes, including DNA replication, RNA transcription, RNA splicing, degradation of nucleic acids and protein synthesis. Defects in protein–nucleic acid interactions are implicated in a number of diseases, ranging from neurological disorders to cancer. Our understanding of these processes will improve as new structures of protein–nucleic acid complexes are solved and the structural details of the interactions are analyzed. However, experimental determination of most protein–nucleic acid complex structures by high-resolution methods is a tedious and difficult process.
Computational techniques complement experimental approaches in elucidating protein–nucleic acid interactions. In silico docking of proteins with nucleic acids, by building theoretical models of the complex structures at atomic details, can yield sufficient information to build a working hypothesis and guide further experimental analyses to identify important amino acids or nucleotide residues.