Prepared as a 10 mM solution in sterile water and subsequently filter-sterilized using 0.45 m filters (Millipore). Cell Culture The GIST882 cell line was kindly provided by Dr. Jonathan Fletcher (Dana-Farber Cancer Institute, Boston, MA) and was described previously [57]. The GIST-T1 cell line was described previously [58]. Cells were cultured in Dulbecco's minimal essential medium high glucose su